Transcranial focused ultrasound (FUS) represents a relatively new modality of non-invasive neuromodulation (brain stimulation).
We are developing world-leading delivery systems.
Explainer
As used in transcranial interfaces, FUS uses low-power sound waves to target structures deep inside the brain.
Sound waves (ultrasound) generated by multiple transmitters converge in the brain to form small pockets of pressure. Unlike magnetic or electrical stimulation, focused ultrasound propagates through the brain’s soft tissue with minimal disruption.
Through mechanical force and/or tiny temperature changes, converging ultrasound beams rapidly impact the electrical properties of brain cells, or neurons, rendering them more or less excitable.
FUS-based neuromodulation alters the connections, or synapses, between neurons, and thereby causes functional changes to entire neural pathways and systems*.
* For sample reference, see Blackmore et al., Molecular Psychiatry, 2021.
Small tweaks to neural pathways in certain regions of the brain can result in significant improvements in motor function, mood, pain perception and even memory and concentration*.
* For review, see Matt et al., Frontiers in Neuroscience, 2024.
The device Grey Matter is building is designed to be used outside of hospitals – even at home – thanks to its versatility: it requires neither continuous image guidance nor subject immobilization.
Our patent-protected technology, originally developed by Dr. Kullervo Hynynen and his team at Sunnybrook Research Institute, sets a new standard for FUS-based neuromodulation and non-invasive brain-machine interfaces.
